One Sophia is located within the Orchard Road precinct and enjoys excellent connectivity, with four MRT stations nearby. Dhoby Ghaut MRT is within walking distance and serves as a major interchange for the North–South Line (Red), North East Line (Purple), and Circle Line (Yellow), providing seamless access across the island.
The area is highly convenient, with an abundance of dining and shopping options close by. Renowned educational institutions in the vicinity include School of the Arts (SOTA), Nanyang Academy of Fine Arts, LASALLE College of the Arts, and Singapore Management University.